Table 1 Distribution of major gangliosides
in rat nervous system detected by MAbs

Rat regionGanglioside
GM1GD1aGD1bGT1bGQ1b

Cerebellar cortex
Molecular layer + +++ + ++ -
Purkinje cell layer - - - - -
Granular layer + + +++ +++ ++
White matter +++ - - + -
Cerebral cortex
Molecular layer (I) + +++ - + -
Ext. granular layer (II) + +++ + - -
Ext. pyramidal layer (III) + +++ ++ ++ -
Int. granular layer (IV) + - +++ + +
Int. pyramidal layer (Va) + + +++ ++ -
Int. pyramidal layer (Vb) + - +++ ++ +
Polymorphic cell layer (VI) + + +++ + +
White matter ++ - + +++ -
Hippocampal formation
  Hippocampus
Alveus ++ - ++ ++ +++
Stratum oriens ++ ++ - + +
Stratum pyramidale - - + - ++
Stratum radiatum - ++ - + -
Stratum lacunosummolelulare ++ - ++ + -
  Dentate gyrus
Polymorphic layer + ++ + + -
Granular layer - - ++ - -
Molecular layer + ++ - ++ -
Spinal cord
  Gray matter
Anterior horn + - +++ +++ ++
Posterior horn + +++ +++ +++ ++
  White matter
Anterior funiculus + - + ++ -
Lateral funiculus + - + ++ -
Posterior funiculus + - + ++ -

1Gangliosides GM1, GD1a, GD1b, GT1b,and GQ1b were detected by five MAbs GMB16, GMR17, GGR12, GMR5, and GMR13, respectively, with indirect immunofluorescence technique.
2+++, strong; ++, moderate; +, weak; -, negative.



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