| 表１ グリコサミノグリカン及び関連糖鎖合成に働く硫酸転移酵素の基質特異性 | |||||
| 番号 | 糖残基の種類と位置 | 精製､クローニングされた酵素 | 略称およびアイソフォーム | 文献 | |
|---|---|---|---|---|---|
| コンドロイチン硫酸及び関連糖鎖 | |||||
| 1 | GalNAc | 6 | Chondroitin 6-sulfotransferase | C6ST | 1, 2 |
| 6 | Chondroitin 6-sulfotransferase-2 | C6ST-2 | 3 | ||
| 2 | GalNAc | 4 | Chondroitin 4-sulfotransferase | C4ST | 4, 5 |
| 4 | Chondroitin 4-sulfotransferase-2 |
C4ST
|
6 | ||
| 4 | GalNAc 4-O-sulfotransferase |
GalNAc4ST
|
7, 8 | ||
| 3 | GalNAc(4SO4) | 6 | GalNAc(4SO4) 6-O- sulfotransferase |
GalNAc4S-6ST
|
9 |
| 4 | GlcA | 2 | Uronosyl 2-O- sulfotransferase |
UA2OST
|
10 |
| 5 | GlcA | 3 | 未同定 | ||
| デルマタン硫酸 | |||||
| 6 | GalNAc | 4 | 未同定 | ||
| 7 | GalNAc | 6 | 未同定 | ||
| 8 | GalNAc(4SO4) | 6 | GalNAc(4SO4) 6-O- sulfotransferase |
GalNAc4S-6ST
|
9 |
| 9 | IdoA | 2 | Uronosyl 2-O- sulfotransferase |
UA2OST
|
10 |
| ケラタン硫酸及び関連糖鎖 | |||||
| 10 | Gal | 6 | Keratan sulfate Gal-6-sulfotransferase | KSGal6ST | 11 |
| 11 | GlcNAc | 6 | GlcNAc 6-O-sulfotransferase | GalNAc6ST | 12 |
| 6 | HEC-GlcNAc 6-O-sulfotransferase |
HEC-GlcNAc6ST
|
13,14 | ||
|
(LSST)
|
|||||
| 6 | I-GlcNAc 6-O-sulfotransferase |
I-GlcNAc6ST
|
15 | ||
| 6 | GlcNAc 6-O-sulfotransferase-4 |
GlcNAc6ST 4
|
3,16,17 | ||
|
(C6ST-2)
|
|||||
| 6 | C- GlcNAc 6-O-sulfotransferase |
C-GlcNAc6ST
|
18,19 | ||
| ヘパラン硫酸、ヘパリン | |||||
| 12 | GlcNAc | 6 | 未同定 | ||
| 13 | GlcN | 2 | N-deacetylase/N-sulfotransferase-1 | NDST-1 | 22,21 |
| 2 | N-deacetylase/N-sulfotransferase-2 |
NDST-2
|
22,23,24 | ||
| 2 | N-deacetylase/N-sulfotransferase-3 |
NDST-3
|
25 | ||
| 2 | N-deacetylase/N-sulfotransferase-4 |
NDST-4
|
26 | ||
| 14 | GlcNS | 6 | Heparan sulfate 6-sulfotransferase-1 | HS6ST-1 | 27,28 |
| 6 | Heparan sulfate 6-sulfotransferase-2 |
HS6ST-2
|
29 | ||
| 6 | Heparan sulfate 6-sulfotransferase-3 |
HS6ST-3
|
29 | ||
| 15 | GlcNS | 3 | Glucosaminyl 3-O-sulfotransferase-1 | 3-O-ST-1 | 30,31 |
| 3 | Glucosaminyl 3-O-sulfotransferase-2 |
3-O-ST-2
|
32,33 | ||
| 16 | GlcN | 2 | Glucosaminyl 3-O-sulfotransferase-3A |
3-O-ST-3A
|
32,33,34 |
| 2 | Glucosaminyl 3-O-sulfotransferase-3B |
3-O-ST-3B
|
32,33,34 | ||
| 17 | IdoA | 2 | Heparan sulfate 2-sulfotransferase | HS2ST | 35,36 |
| 18 | GlcA | 2 | Heparan sulfate 2-sulfotransferase | HS2ST | 37 |
| Return | |||||
| 表2 硫酸転移酵素遺伝子のアミノ酸配列の相同性による分類 | ||||||
| 遺伝子グループ | クローニングされた遺伝子 | 種 | アミノ酸 残基数 |
グループ内の
相同性 |
文献 | |
|---|---|---|---|---|---|---|
| C6ST グループ |
C6ST | chick |
458
|
31
| 2 | |
| NSIST | Torpedo |
441
|
29
| 39 | ||
| KSGal6ST | human |
411
|
35
| 11 | ||
| GlcNAc6ST | mouse |
483
|
37
| 12 | ||
| HEC-GlcNAc6ST | human |
386
|
100
| 13,14 | ||
| (LSST) | ||||||
| I-GlcNAc6ST | human |
390
|
52
|
15 | ||
| C6ST-2 | human |
486
|
36
|
3,16,17 | ||
| (GlcNAc6ST-4) | ||||||
| C-GlcNAc6ST | human |
364
|
54
| 18 | ||
| C4ST グループ |
C4ST | mouse |
352
|
100
| 5 | |
| C4ST-2 | human |
414
|
38
| 6 | ||
| HNK-1 ST | rat |
356
|
28
| 40 | ||
| GalNAc4ST | human |
424
|
36
| 7,8 | ||
| NDST グループ |
NDST-1 | rat |
882
|
71
|
30
|
21 |
| NDST-2 | mouse |
883
|
67
|
30
|
24 | |
| NDST-3 | human |
873
|
81
|
33
|
25 | |
| NDST-4 | human |
872
|
100
|
32
|
26 | |
| 3-OST-1 | mouse |
311
|
100
|
31 | ||
| 3-OST-2 | human |
367
|
41
|
32 | ||
| 3-OST-3A | human |
406
|
40
|
32 | ||
| 3-OST-3B | human |
390
|
40
|
32 | ||
| HS6ST グループ |
HS6ST-1 | human |
401
|
100
| 28 | |
| HS6ST-2 | mouse |
506
|
50
| 29 | ||
| HS6ST-3 | mouse |
470
|
55
| 29 | ||
| HS2ST グループ |
HS2ST | hamster |
356
|
100
| 36 | |
| SD protein | Drosophila |
363
|
43
| 41 | ||
| Pipe ST2 | Drosophila |
403
|
28
|
42 | ||
| UA2OST | human |
406
|
26
| 10 | ||
| Return | ||||||